Pain Medications: Opioids vs Non-Opioids - What’s Safe and What’s Not

7 December 2025 13 Comments Joe Lindley

When you hurt - whether it’s a bad back, a sore knee, or pain after surgery - you want relief. Fast. But not all pain meds are created equal. And the difference between an opioid and a non-opioid isn’t just about strength. It’s about risk. Long-term safety. Even your life.

What Are Opioids, Really?

Opioids are powerful drugs that bind to special receptors in your brain and spinal cord to block pain signals. They include prescription pills like oxycodone, hydrocodone, and morphine, and synthetic versions like fentanyl. They work - quickly and strongly. But they also come with a dark side: addiction, overdose, and serious health damage.

Back in the 1990s and early 2000s, doctors prescribed opioids freely for everything from back pain to headaches. But the cost became clear. In 2021, over 80,000 people in the U.S. died from opioid overdoses. That’s not a number. That’s 80,000 families shattered. The CDC declared it a public health emergency in 2017 - and it’s still going.

Here’s what you might not know: long-term opioid use doesn’t just raise your risk of addiction. It increases your chance of a heart attack. One study of nearly 300,000 people found that taking opioids for more than 180 days over three and a half years raised the risk of heart attack by more than 160%. And if you’re on 120 mg or more of morphine equivalent per day, your risk jumps by almost 60%.

Non-Opioids: The Quiet Alternative

Non-opioid pain relievers include everyday drugs like ibuprofen, naproxen, acetaminophen, and now, newer options like Journavx - approved by the FDA in March 2024. These don’t target your brain’s reward system. They work locally on inflammation or nerve signals.

And here’s the surprise: they often work just as well - or better.

The SPACE trial, a major 12-month study published in JAMA in 2018, compared opioids to non-opioids in 240 patients with chronic back or joint pain. At the end of the year, both groups reported similar levels of pain interference in daily life. But the non-opioid group had significantly lower pain intensity. They felt less pain. And they had fewer side effects: less nausea, no constipation, no drowsiness, and zero risk of addiction.

Even more telling? In patients with hip or knee osteoarthritis, the non-opioid group had a full point lower pain interference score - a big difference in real life. Imagine being able to walk to the store without pain. That’s what that number means.

What About Kids?

You might think opioids are necessary for severe pain in children. But the evidence says otherwise.

A 2024 review in Pediatrics looked at five randomized trials involving kids with post-surgery or fracture pain. In every case, ibuprofen or acetaminophen worked just as well as morphine or codeine. But the opioid groups had way more side effects: vomiting, drowsiness, dizziness - and in one study, low oxygen levels.

One trial with 48 children given codeine or tramadol found that more than half had nausea or constipation. No one died. But many suffered. And no one had better pain control.

Doctors are starting to change their habits. In Australia, Canada, and the U.S., guidelines now say: start with ibuprofen or acetaminophen. Save opioids for emergencies - not routine care.

A doctor and child in a hospital room, with a checklist promoting non-opioid pain relief and opioids hidden away.

Why the Shift in Guidelines?

It’s not just one study. It’s dozens. And it’s led to a sweeping change in medical policy.

The CDC’s 2022 clinical guideline says clearly: “Use nonopioid therapy as the preferred treatment for subacute and chronic pain.” That’s not a suggestion. It’s a standard. The guideline even points to the SPACE trial as the key evidence behind this rule.

The American College of Physicians, the Veterans Health Administration, and the California Medical Board all say the same thing: opioids aren’t better for long-term pain. They’re riskier. And the benefits don’t justify the dangers.

The VA’s own data shows opioids were not superior to non-opioids in pain relief - but caused more side effects. That’s why their pain program now trains doctors to have honest conversations: “This pill might help your pain today, but it could hurt your health tomorrow.”

The New Hope: Journavx and Beyond

In March 2024, the FDA approved Journavx - the first new non-opioid painkiller in decades. It’s not a miracle drug. But it’s a breakthrough.

It was tested in over 800 patients after surgery. Those who took Journavx had significantly less pain than those who took placebo. And it worked without the risks of opioids. Patients could still take ibuprofen if needed - but many didn’t.

This isn’t just about one drug. It’s about a new direction. The FDA is now actively funding research into non-opioid alternatives. Why? Because they know the old model is broken. We can’t keep prescribing drugs that kill more people than they help.

A cityscape with crumbling opioid towers and safe, glowing non-opioid buildings, symbolizing safer pain management.

What Should You Do?

If you’re on opioids for chronic pain - and you’ve been on them for months or years - talk to your doctor. Don’t stop cold turkey. But ask: “Is this still the safest option?”

Ask about:

Switching to NSAIDs like naproxen or celecoxib
Physical therapy or exercise programs
Acupuncture or cognitive behavioral therapy
Topical creams (like lidocaine or diclofenac gel)

If you’ve been prescribed opioids for acute pain - like after surgery - ask: “Can I start with ibuprofen and acetaminophen first? Only use the opioid if I really need it.”

Many people don’t realize they can mix medications safely. Taking 500 mg of acetaminophen and 400 mg of ibuprofen together - spaced out - often works better than a single opioid pill. And it’s far safer.

The Bottom Line

Opioids aren’t evil. They have a place - in cancer pain, end-of-life care, or after major trauma. But for most everyday pain - back pain, arthritis, headaches, post-surgery discomfort - they’re the wrong tool.

Non-opioid options are safer. They work. And they’re getting better.

Don’t let fear of pain push you toward a drug that could change your life for the worse. Ask questions. Demand alternatives. Your body will thank you.