A Guide to Storing and Handling Luliconazole Cream

30 October 2025 15 Comments Joe Lindley

Storing and handling luliconazole cream correctly isn’t just about keeping it on the shelf-it’s about making sure it works when you need it most. Luliconazole is a powerful antifungal used to treat skin infections like athlete’s foot, jock itch, and ringworm. If it’s not stored right, the active ingredient can break down, making your treatment less effective-or worse, useless. This isn’t theoretical. I’ve seen patients come in with a tube of cream they bought six months ago, convinced it should still work, only to find the infection came back because the cream had been sitting in a hot bathroom for weeks.

What is luliconazole cream and why does storage matter?

Luliconazole cream is a topical antifungal medication. Its active ingredient, luliconazole, works by stopping fungi from building their cell walls. It’s strong enough to clear up stubborn infections in as little as one week, which is why doctors often prescribe it for resistant cases. But this potency depends on stability. The chemical structure of luliconazole can degrade under heat, light, or moisture. Once that happens, the concentration drops below therapeutic levels. A 2023 study from the Journal of Clinical Dermatology found that antifungal creams exposed to temperatures above 30°C for more than two weeks lost up to 18% of their active ingredient. That’s not a small loss-it’s enough to turn a cure into a waste of time and money.

Where should you store luliconazole cream?

The manufacturer’s instructions say to store it at room temperature. That means between 15°C and 25°C. In practice, that rules out your bathroom cabinet. Bathroom temperatures can easily hit 30°C or higher during a hot shower, and humidity from steam can seep into the tube. Instead, keep it in a cool, dry place like a bedroom drawer, a closet shelf, or even the bottom shelf of your kitchen cabinet-away from the stove or dishwasher. If you live in a hot climate like Sydney, where summer temps regularly climb above 35°C, don’t assume your air-conditioned house keeps everything cool. The back of a drawer near a window can still get warm. Pick a spot that’s consistently shaded and not near any heat source.

What about refrigeration?

No, you don’t need to refrigerate luliconazole cream. In fact, cold temperatures can cause the cream to separate or become grainy. The base ingredients-like petrolatum and emulsifiers-are designed to stay stable at room temperature. Putting it in the fridge might seem like a smart move, but it can actually make the product harder to apply and reduce its effectiveness. If you accidentally leave it in the fridge for a few days, don’t panic. Let it sit at room temperature for 24 hours and check the texture. If it’s smooth again, it’s fine to use. If it looks lumpy, watery, or smells off, throw it out.

How to handle the tube properly

Always wash your hands before applying the cream. That’s basic, but it’s also critical. You’re putting medication on broken or infected skin. If your hands carry bacteria or dirt, you risk introducing a secondary infection. After applying, wipe the tube’s opening with a clean tissue. Don’t let cream dry on the cap or nozzle. That buildup can trap moisture and bacteria, which can contaminate the rest of the tube. Never share your tube with someone else-even if they have the same infection. Fungal infections are contagious, and sharing tubes can spread the fungus or introduce new strains.

A melted tube of luliconazole cream left on a hot car dashboard under direct sunlight.

How long can you keep it after opening?

Most topical creams like luliconazole are good for 12 months after opening, but check the label. Some tubes have a small symbol that looks like an open jar with a number inside-like "12M"-that tells you how many months it’s safe to use after first opening. If there’s no symbol, assume 12 months. But don’t wait that long if you notice changes. If the cream changes color (turns yellow or brown), smells strange (like rancid oil), or becomes runny or hard, stop using it. These are signs of degradation or contamination. Even if it’s within the 12-month window, if it doesn’t look or feel right, it’s not safe.

What to do if you leave it in the car or a hot place

Accidents happen. You forget the cream in the car on a 38°C day. You leave it on the windowsill during a heatwave. If it’s been exposed to temperatures above 40°C for more than a few hours, don’t use it. Heat can permanently alter the chemical structure. There’s no way to tell just by looking if it’s still effective, and guessing isn’t worth it. A failed treatment means the infection lingers, spreads, or becomes resistant. If you’re unsure, contact your pharmacist. They can check the batch and advise whether it’s safe. Most pharmacies will replace it for free if it was stored improperly through no fault of the patient.

Travel tips for luliconazole cream

If you’re flying, pack the tube in your carry-on. Checked baggage can sit in unpressurized cargo holds where temperatures drop below freezing or soar above 50°C. That’s worse than leaving it in a car. In your carry-on, keep it in a sealed plastic bag with your other medications. If you’re traveling to a hot country, carry a small insulated pouch or even a wrapped ice pack (not frozen, just cool) to keep it stable. Don’t rely on hotel room temperatures-they’re often set for comfort, not medication storage.

A pharmacist giving a new cream tube to a patient while showing common storage errors.

What to do with expired or unused cream

Never flush it down the toilet or throw it in the trash. Medications can leach into water supplies or attract animals. Most pharmacies offer medication take-back programs. In Australia, you can drop off unused or expired creams at any pharmacy that participates in the Return of Unwanted Medicines (RUM) program. It’s free and safe. If your pharmacy doesn’t have a drop box, call your local council-they often host periodic collection days. Proper disposal protects the environment and keeps kids and pets from accidentally getting into it.

Signs your luliconazole cream has gone bad

Change in color (yellowing, darkening, or spotting)
Unusual odor (rancid, sour, or chemical smell)
Texture change (separated, watery, lumpy, or too hard)
Expiration date has passed
Tube was left in extreme heat or direct sunlight

If any of these apply, toss it. Don’t try to stretch it out. Fungal infections don’t wait, and neither should your treatment.

Common mistakes people make

People assume all creams are the same. They store luliconazole next to their moisturizer in the bathroom. They use it after it’s been open for two years. They leave it in the car during a weekend trip. They ignore the expiration date because "it still looks fine." These aren’t small oversights-they’re risks that lead to treatment failure. One patient I worked with used the same tube for eight months, even after the infection cleared. She thought it was a "preventative". It wasn’t. The cream had degraded, and when she got another infection, it didn’t work. She ended up needing a stronger prescription.

Another mistake: applying it only when symptoms are bad. Luliconazole works best when used exactly as prescribed-once daily, for the full course, even if the itching stops after two days. Skipping doses or stopping early can lead to resistant fungi. And storing it poorly makes that problem worse.

Can I use luliconazole cream after the expiration date?

No. The expiration date is based on stability testing. After that date, the active ingredient may have broken down enough to be ineffective. Even if the cream looks normal, you can’t trust its potency. Using expired antifungal cream can lead to incomplete treatment and recurring infections.

Is it safe to store luliconazole cream in the fridge?

No. Refrigeration can cause the cream’s base to separate or become grainy, making it harder to apply and potentially reducing absorption. Store it at room temperature (15-25°C) instead. If it was accidentally refrigerated, let it return to room temperature for 24 hours and check the texture. If it’s smooth, it’s still usable.

How do I know if my luliconazole cream has gone bad?

Look for changes in color (yellowing or dark spots), smell (rancid or chemical odor), or texture (separation, lumpiness, or excessive thinning). If the tube was exposed to high heat or left open for more than 12 months, discard it-even if it looks fine.

Can I share my luliconazole cream with someone else?

Never. Fungal infections are contagious, and sharing tubes can spread the infection or introduce new strains of fungus. Always use your own tube, and wash your hands before and after applying.

What should I do if I accidentally left my luliconazole cream in a hot car?

If it was exposed to temperatures above 40°C for more than a few hours, do not use it. Heat can permanently damage the active ingredient. Contact your pharmacist-they can advise whether to replace it. Most pharmacies will provide a new tube at no cost if the medication was compromised due to improper storage.

Next steps for safe use

Write the opening date on the tube with a marker when you first open it. That way, you’ll know exactly how long it’s been out. Set a reminder on your phone for 12 months. Keep the tube in a cool, dry place-not the bathroom, not the car, not the windowsill. If you’re unsure about storage, ask your pharmacist. They’ve seen what happens when people skip these steps. Don’t wait until the infection comes back to realize your cream didn’t work because it was stored wrong.

Tags: luliconazole cream storage instructions antifungal cream topical medication skin infection treatment