Provera (medroxyprogesterone): what it does and how to use it

Need a clear take on Provera? This is the oral form of medroxyprogesterone. Doctors use it to treat things like irregular bleeding, absence of periods (amenorrhea), part of hormone therapy, and some cases of endometriosis. It’s not the same as the Depo-Provera shot, though they share the same active drug.

Why would you take it? If your cycle is irregular or you need a short course of progesterone for hormonal balance, Provera is often prescribed. It can trigger a withdrawal bleed and reset your cycle in many cases.

How Provera is used and typical doses

Common short-course dosing is 5–10 mg by mouth once daily for 5–10 days to stop abnormal bleeding or to induce a period. For amenorrhea, doctors often use 10 mg daily for five to ten days. As part of hormone replacement therapy, a doctor may recommend 10 mg for 12–14 days each month to protect the uterine lining when estrogen is used.

Remember: Depo-Provera is the injectable form (150 mg IM every 12 weeks) and is used as a long-acting contraceptive. Don’t swap forms or change timing without your prescriber’s okay.

Side effects, safety tips, and interactions

Common side effects include spotting, changes in bleeding patterns, mood swings, headaches, and breast tenderness. Some people report weight changes. With long-term use of injectable medroxyprogesterone, there’s a risk of reduced bone density. That’s why doctors monitor use over time.

Certain conditions mean you shouldn’t take Provera without careful review: current breast cancer, unexplained vaginal bleeding, or active blood clots. If you have liver disease or a history of stroke, discuss risks with your provider.

Watch out for drug interactions. Enzyme inducers like rifampin, some anticonvulsants, and St. John’s Wort can lower Provera levels. Always tell your clinician about prescription drugs, herbal supplements, and even strong over-the-counter remedies.

Quick practical tips: if you miss an oral dose, take it as soon as you remember that day and then continue your schedule. Don’t double up doses. If bleeding patterns change or you have severe side effects—seek medical advice.

Buying and prescriptions: Provera is a prescription medicine. Use a licensed pharmacy or a reputable online pharmacy that requires a prescription and shows accreditation. Avoid sites that promote “no-prescription” sales or suspiciously low prices without clear contact info.

Got questions for your doctor? Ask how long you should stay on Provera, whether it affects fertility, and whether you need bone density checks for long-term use. Small talk with your clinician now can prevent bigger problems later.

Need more detail or a specific scenario explained? Tell me the situation and I’ll lay out the steps you can discuss with your healthcare provider.